Localized immune tolerance from FasL-functionalized PLG scaffolds

Layered PLG scaffolds for in vivo plasmid delivery.

Gene delivery from tissue engineering scaffolds can induce localized expression of tissue inductive factors to direct the function of progenitor cells, either endogenous or transplanted. In this report, we developed a layering approach for fabricating scaffolds with encapsulated plasmid, and investigated in vivo gene transfer following implantation into intraperitoneal fat, a widely used site f...

Functionalized Biomaterials - Oxygen Releasing Scaffolds

The advancement in tissue engineering has reached a considerably high level with major achievements, especially in mimicking the nature in terms of morphology, structure, functionality and mechanical strength. Nonetheless, the current technology still fails to deliver the urgent need in producing construct of larger volume such as organs, which will be more effective in tackling chronic disease...

Dual Role of Fas/FasL-Mediated Signal in Peripheral Immune Tolerance

Fas-mediated apoptosis contributes to physiological and pathological cellular processes, such as differentiation and survival. In particular, the roles of Fas in immune cells are complex and critical for the maintenance of immune tolerance. The precise pathways and unique functions associated with Fas/FasL-mediated signaling in the immune system are known. The dual character of Fas/FasL-mediate...

Functionalized scaffolds to enhance tissue regeneration

Tissue engineering scaffolds play a vital role in regenerative medicine. It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation. In this review, we summarize the development and trends of functional scaffolding biomaterials including electrically conducting hydrogels and nano-com...

Protein Establish Robust Localized Pancreatic Islets Engineered with SA-FasL